Pyridoxal-5-Phosphate
(Vitamin B6)

Main benefits:
Hormones. Mood. PMS. Menopause. Detox. Prostate.

Origin and Source:
Pyridoxal-5-Phosphate (P5P) is the biologically active form of Vitamin B6 — meaning it’s already converted into the form your body actually uses. While conventional B6 (like pyridoxine hydrochloride) must be processed by the liver, P5P is immediately bioavailable, making it ideal for individuals with stress, inflammation, hormonal imbalance, or compromised liver methylation.

NØØT Classification:

P5P is a Neurohormonal Coenzyme Matrix — not a phytogen, nootropic, or adaptogen, but a functional compound essential for emotional regulation, hormonal detox, energy metabolism, and nervous system balance. It’s a foundational support in NØØT formulations targeting PMS, mood stability, burnout, and neurotransmitter synthesis.

Key Benefits and Science

Hormonal Detox & PMS Support

P5P plays a key role in estrogen clearance and phase II liver detoxification, supporting hormonal balance and PMS symptom relief.
Commonly used to address cycle-related irritability, bloating, and breast tenderness — especially in high-estrogen states.

Mood, Serotonin & Dopamine Balance

Essential for the synthesis of serotonin, dopamine, GABA, and norepinephrine — critical neurotransmitters for mood, focus, and emotional clarity.
Often included in protocols for anxiety, low mood, and hormone-related mood shifts.

Energy Metabolism & Fatigue

Acts as a coenzyme in the metabolism of proteins, fats, and carbohydrates — directly influencing mitochondrial energy output.
Commonly used in fatigue, adrenal depletion, and chronic stress recovery formulas.

Immune Function & Inflammation

Supports optimal function of immune cells and may help modulate inflammatory markers.
Relevant in protocols for immune fatigue, chronic stress, and inflammation-related hormonal disruption.

Why It’s Good for You

P5P is the precision form of Vitamin B6 your body actually recognizes and uses. If you’re struggling with hormone swings, mood volatility, low energy, or detox resistance, this coenzyme doesn’t just support — it activates. It’s what turns amino acids into neurotransmitters, hormones into balance, and nutrients into power.

Usage

At NØØT, P5P is included in formulas for hormonal rhythm, PMS support, emotional balance, and stress-related fatigue. Often paired with Magnesium Bisglycinate, L-Theanine, and Ashwagandha to enhance mood and nervous system synergy.

Why We Include It in NØØT Formulas

Active, bioavailable form of B6 — no liver conversion required
Used in formulations for PMS, estrogen detox, neurotransmitter support, and stress resilience
Commonly integrated in blends addressing mood instability, chronic fatigue, and burnout recovery
Cruelty-free, filler-free, and third-party tested for purity, potency, and methylation safety
Essential in protocols supporting women’s health, brain chemistry, and emotional clarity

📚 Reference Example:

Leklem JE. Vitamin B6: a status report. J Nutr. 1990.
Shan A et al. The role of Vitamin B6 in women's health: from PMS to depression. Nutr Rev. 2021.