Nicotinamide Riboside
(NR)

Main benefits:
NAD+. ATP. Longevity. Cellular repair. Energy.

Origin and Source:
Nicotinamide Riboside (NR) is a next-generation form of Vitamin B3, found naturally in trace amounts in milk and other foods. It’s known for its ability to efficiently increase NAD+ levels — the critical coenzyme involved in cellular energy, DNA repair, and healthy aging. We use a stabilized, bioavailable form to support advanced cellular regeneration and mitochondrial function.

 

NØØT Classification:

Nicotinamide Riboside is a Longevity-Activating Nutrient Matrix — not a phytogen, adaptogen, or nootropic, but a highly functional compound used in both blended stacks and as a standalone. It is the key ingredient in RejuveNAD+, NØØT’s dedicated NAD+ support formula. Included for its role in mitochondrial energy, cellular repair, and age-related performance resilience, NR is a foundational tool in NØØT’s longevity system.

Key Benefits and Science

NAD+ Production & Cellular Energy

• Known to rapidly boost NAD+ levels, which decline with age and stress.
  
• Supports mitochondrial function, energy metabolism, and cellular vitality.

DNA Repair & Longevity Pathways

• Activates sirtuins and PARP enzymes involved in DNA repair and longevity regulation.
  
• Frequently included in protocols focused on anti-aging, cellular detox, and regeneration.

Brain Health & Cognitive Performance

• NAD+ is essential for neurotransmitter balance, memory, and mental clarity.
  
• Studied for its potential in neuroprotection and cognitive aging support.

Metabolic Health & Inflammation

• Supports healthy glucose and lipid metabolism, with applications in metabolic syndrome and chronic inflammation.
  
• May reduce "inflammaging" — the low-grade inflammation linked to biological aging.

Skin Health & Visible Aging

• NAD+ impacts collagen production, elasticity, and cell turnover, making NR a valuable internal support for skin health.
  
• Often used in beauty-from-within formulations for a more youthful appearance.

Why It’s Good for You

Nicotinamide Riboside is a cellular upgrade at the molecular level. Whether you’re seeking more energy, supporting your brain as you age, or looking to optimize recovery and resilience, NR supports the repair and renewal systems your body needs most — from the inside out.

Usage

Nicotinamide Riboside is used both as a standalone compound (as featured in RejuveNAD+) and as a core ingredient in stacked longevity protocols. It works synergistically with Resveratrol, PQQ, CoQ10, and Magnesium for full mitochondrial and anti-aging support.

Why We Include It in NØØT Formulas

• Recognized for its role in NAD+ production, DNA repair, mitochondrial renewal, and cellular detox
• Featured in RejuveNAD+, and integrated into stacks targeting fatigue, inflammation, and performance longevity
• Cruelty-free, filler-free, and third-party tested for purity, NAD+ conversion, and stability
• Supports those exploring biohacking, healthy aging, and resilience under chronic stress

 

📚 Reference Example:

• Trammell SAJ et al. Nicotinamide riboside is uniquely and orally bioavailable in humans to boost NAD+ levels. Nat Commun. 2016.

• Martens CR et al. Chronic NR supplementation increases NAD+ and reduces blood pressure in middle-aged and older adults. Nat Commun. 2018.