Magnolia Extract
(Magnolia officinalis)

Main benefits:
Anxiety. Sleep. Cortisol. Mood. Inflammation.

Origin and Source:
Traditionally used in Chinese and Japanese medicine (Hou Po), Magnolia officinalis has been a calming botanical for over 2,000 years. The extract — typically derived from the bark — is rich in honokiol and magnolol, two unique bioactive compounds studied for their impact on cortisol regulation, anxiety relief, and neuroinflammation. At NØØT, we use a standardized extract for honokiol, optimized for absorption and emotional modulation.

 

NØØT Classification:

Magnolia Extract is a Neuroendocrine Regulator — not a classic Adaptogen, Nootropic, or Phytogen, but a deeply valuable inclusion in NØØT formulas due to its effects on emotional balance, stress resilience, and nervous system repair. It is particularly relevant for individuals dealing with high cortisol, mood swings, sleep disruption, or burnout-related symptoms.

 

Key Benefits and Science

Anxiety, Irritability & Mood Swings

• Commonly used for emotional regulation in perimenopause, PMDD, and chronic anxiety states.
  
• Honokiol binds to GABA receptors, promoting a calm state without sedation or dependency.

Cortisol Regulation & Stress-Linked Weight

• Shown in studies to modulate HPA axis activity, reducing elevated cortisol levels linked to abdominal fat gain, cravings, and fatigue.
  
• Used in protocols addressing stress-driven metabolic imbalance and adrenal overload.

Sleep Support & Nervous System Reset

• Supports deep, uninterrupted sleep in those with cortisol-induced insomnia.
  
• Helps shift the body into a parasympathetic state, restoring recovery cycles after long-term stress.

Inflammation & Neuroprotection

• Honokiol has been studied for its role in reducing neuroinflammation, which may benefit individuals with brain fog, trauma recovery, or cognitive burnout.
  
• Also supports gut-brain signaling by lowering systemic inflammatory load.

 

Why It’s Good for You

Magnolia Extract is emotional intelligence in botanical form. Whether you’re navigating hormone-driven mood swings, emotional fatigue, or high-cortisol burnout, this extract supports deep calm and mental clarity — without sedation or withdrawal. It helps retrain your nervous system to return to balance and resilience.

 

Usage

Used in NØØT blends designed for hormonal mood support, cortisol regulation, burnout recovery, and restful sleep. Often paired with L-Theanine, Lemon Balm Phospholipids, and Magnesium Bisglycinate for layered emotional and neurological support.

 

Why We Include It in NØØT Formulas

• Included for its studied role in anxiety relief, sleep quality, cortisol balance, and neuroinflammation.
  
• Commonly used for individuals experiencing perimenopausal mood shifts, trauma-related stress, high-cortisol weight gain, and sleep issues.
  
• Cruelty-free, filler-free, and standardized for honokiol and magnolol content.
  
• Integrated into formulas that support deep nervous system reset, emotional clarity, and hormonal resilience.
  
• Third-party tested for identity, purity, and consistency.

 

📚 Reference Example:

• Kuribara H et al. Behavioral pharmacological characteristics of honokiol, an anxiolytic agent isolated from Magnolia bark. Jpn J Pharmacol. 2000.

• Zhang M et al. Anti-anxiety effect of honokiol in rats exposed to chronic unpredictable mild stress. Neurochem Res. 2013.