Berberine Hydrochloride
(Berberis aristata)

Main benefit:
Blood sugar. Metabolism. Gut. Detox. Inflammation.

Origin and Source:
Extracted from the roots and bark of Berberis aristata, a medicinal plant long revered in Traditional Chinese and Ayurvedic medicine, Berberine Hydrochloride is a golden alkaloid with a long legacy in blood sugar regulation (Diabetis prevention and cure) and metabolic restoration. At NØØT, we use a highly bioavailable HCl form for maximum potency and fast cellular uptake.

NØØT Classification:

Berberine is a Metabolic Phytogen — widely integrated into protocols for blood sugar balance, insulin sensitivity, gut health, and even cellular longevity. While not traditionally categorized as a nootropic or adaptogen, we include it for its multisystem benefits rooted in mitochondrial health and metabolic optimization.

Key Benefits and Science

Blood Sugar Balance

Extensively studied for its ability to support healthy glucose metabolism and insulin sensitivity — often compared to pharmaceutical interventions like metformin.
Commonly used to reduce sugar spikes, stabilize energy, and support fasting protocols.

Gut-Brain Axis & Microbiome

Modulates gut flora by inhibiting harmful bacteria while supporting beneficial strains — making it a powerful ally in restoring microbiome balance.
Supports reduced bloating, improved digestion, and mental clarity via the gut-brain connection.

Weight Management & Fat Metabolism

Influences AMPK (adenosine monophosphate-activated protein kinase), often referred to as the body’s “metabolic master switch.”
Supports fat oxidation, metabolic efficiency, and reduced lipid accumulation.

Inflammation & Longevity

Acts as a powerful anti-inflammatory and antioxidant, supporting healthy aging and cellular defense against oxidative stress.
Studied in connection with cholesterol modulation and inflammatory disease risk.

Why It’s Good for You

Berberine is a true multi-tasker — a natural tool for those navigating blood sugar swings, gut issues, or metabolic overload. Whether you're optimizing intermittent fasting, working on hormonal balance, or building longevity from the inside out, Berberine helps activate your body’s deeper intelligence.

Usage

Take Berberine Hydrochloride consistently with meals or during your fasting window to support blood sugar balance, gut health, and metabolic flow. At NØØT, we pair it with synergistic botanicals to amplify its full-spectrum benefits.

Why We Include It in NØØT Formulas

Integrated into blends targeting metabolic resilience and gut restoration.
Selected for its synergistic role alongside probiotics, adaptogens, and detox agents.
Filler-free, cruelty-free, and standardized for bioavailable performance.
Research-backed for blood sugar, inflammation, and longevity — without pharmaceutical side effects.
Third-party tested to meet the highest standards of purity, potency, and safety.